4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

Base Information

• Chemical Name: 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine
• CAS No.: 129609-36-5
• Molecular Formula: C₁₅H₁₁F₃N₄O
• Molecular Weight: 320.274

Synonyms:4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

Chemical Property of 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

Chemical Property:

Purity/Quality:

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Technology Process of 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

There total 4 articles about 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3-(4-Methoxyphenylmethyl)-4-(3-trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine (129609-31-0) → 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine (129609-36-5)

Guidance literature:

With trifluoroacetic acid; at 65 ℃; for 5h;

Reference yield:

1-pyrrolidinocyclopent-1-ene (7148-07-4) → 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine (129609-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / triethylamine / CH₂Cl₂ / 1 h / -30 °C

2: 51 percent / p-toluenesulfonic acid / benzene / 18 h

3: 69 percent / potassium t-butoxide, t-butyl alcohol / 96 h / Ambient temperature

4: 75 percent / trifluoroacetic acid / 5 h / 65 °C

With potassium tert-butylate; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; tert-butyl alcohol; In dichloromethane; benzene;

Reference yield:

<5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone (129609-21-8) → 4-(3-Trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine (129609-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 51 percent / p-toluenesulfonic acid / benzene / 18 h

2: 69 percent / potassium t-butoxide, t-butyl alcohol / 96 h / Ambient temperature

3: 75 percent / trifluoroacetic acid / 5 h / 65 °C

With potassium tert-butylate; toluene-4-sulfonic acid; trifluoroacetic acid; tert-butyl alcohol; In benzene;

upstream raw materials:

3-(4-Methoxyphenylmethyl)-4-(3-trifluoromethylphenyl)-8-oxo-4,5,6,7-tetrahydrocyclopenta-1,2,3-triazolo<4,5-b>pyridine

1-pyrrolidinocyclopent-1-ene

<5-Chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl><2-(1-pyrrolidinyl)-1-cyclopenten-1-yl>methanone

<2-(3-Trifluoromethylphenylamino)-1-cyclopenten-1-yl><5-chloro-1-(4-methoxyphenylmethyl)-1H-1,2,3-triazol-4-yl>methanone

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