6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione

Base Information

• Chemical Name: 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione
• CAS No.: 1334727-49-9
• Molecular Formula: C₂₀H₂₀N₂O₅S
• Molecular Weight: 400.455

Synonyms:6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione

Chemical Property of 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione

Chemical Property:

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Technology Process of 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione

There total 2 articles about 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C19H18O6 (75403-98-4) + thiourea (17356-08-0) → 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione (1334727-49-9)

Guidance literature:

With potassium carbonate; In ethanol; for 12h; Reflux;

DOI:10.1002/ardp.201100077

Reference yield:

1-(benzo[d][1,3]dioxol-6-yl)ethanone (3162-29-6) → 6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione (1334727-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 20 °C

2: potassium carbonate / ethanol / 12 h / Reflux

With potassium carbonate; potassium hydroxide; In ethanol; 1: Claisen Schmidt condensation;

DOI:10.1002/ardp.201100077

Reference yield: 63.0%

6-benzo[1,3]dioxol-5-yl-4-(3,4,5-trimethoxyphenyl)-3,4-dihydro-1H-pyrimidine-2-thione (1334727-49-9) + 2-chloro-N-(4-chlorophenyl)acetamide (3289-75-6) → C28H24ClN3O6S (1334727-52-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1002/ardp.201100077

upstream raw materials:

C₁₉H₁₈O₆

thiourea

1-(benzo[d][1,3]dioxol-6-yl)ethanone

Downstream raw materials:

C₂₈H₂₄ClN₃O₆S

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