tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate
CAS No.:1447121-08-5
Molecular Formula:C₂₀H₃₁FN₂O₅S
Molecular Weight:430.541
Hs Code.:

Synonyms:tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 398456-87-6
2-fluoro-4-(methanesulfonyl)phenol

: 1447123-00-3
tert-butyl 4-(methyl(2-(methylsulfonyloxy)ethyl)amino)piperidine-1-carboxylate

: 1447121-08-5
tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 864655-25-4
tert-butyl 4-((2-hydroxyethyl)(methyl)amino)piperidine-1-carboxylate

: 1447121-08-5
tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / chloroform / 0.5 h / 0 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

With sodium hydride; triethylamine; In chloroform; N,N-dimethyl-formamide;

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 1447121-08-5
tert-butyl 4-((2-(2-fluoro-4-(methylsulfonyl)phenoxy)ethyl)(methyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 20 °C

2.1: triethylamine / chloroform / 0.5 h / 0 °C / Inert atmosphere

2.2: 3 h / 20 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 3 h / Inert atmosphere; Reflux

With sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;