1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

Base Information

Chemical Name:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil
CAS No.:131194-25-7
Molecular Formula:C₂₄H₃₆N₂O₄SSi₂
Molecular Weight:504.798
Hs Code.:

Synonyms:1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

Suppliers and Price of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

There total 2 articles about 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123027-47-4
1-<<2-(tert-butyldimethylsiloxy)ethoxy>methyl>-6-(phenylthio)uracil

: 131194-25-7
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium 2,2,6,6-tetramethylpiperidide (LTMP), 2.) iodine / 1.) THF, -70 deg C, 1 h, 2.) -70 deg C, 1 h

2: Et₃N, bis(triphenylphosphine)palladium(II) chloride, copper(I) chloride / 1.) MeCN, 60 deg C, 2 h, 2.) 60 deg C, 1.5 h

With bis(triphenylphosphine)palladium(II)-chloride; 2,2,6,6-tetramethylpiperidinyl-lithium; iodine; triethylamine; copper(l) chloride;
DOI:10.1021/jm00105a055

Reference yield:

: 125057-21-8
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-5-iodo-6-(phenylthio)uracil

: 1066-54-2
trimethylsilylacetylene

: 131194-25-7
1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil

Guidance literature:: With bis(triphenylphosphine)palladium(II)-chloride; triethylamine; copper(l) chloride; Yield given. Multistep reaction; 1.) MeCN, 60 deg C, 2 h, 2.) 60 deg C, 1.5 h;
DOI:10.1021/jm00105a055