<1S-(1R,2S,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Base Information

Chemical Name:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide
CAS No.:135727-10-5
Molecular Formula:C₄₁H₅₈N₆O₉S₂
Molecular Weight:843.078
Hs Code.:

<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Synonyms:<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

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Chemical Property of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

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Technology Process of <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

There total 14 articles about <1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 135703-72-9
{4-[(R)-2-Amino-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

: 135727-10-5
(4-{(R)-2-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-ethyl}-thiazol-2-yl)-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00092a006

Reference yield:

: 124278-39-3
N-(4-MorpholinYlsulfonyl)-L-phenylalanine

: 135703-72-9
{4-[(S)-2-Amino-2-((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-thiazol-2-yl}-carbamic acid benzyl ester

: 135727-10-5
<1S-(1R*,2S*,3R*)>-N-(4-morpholinylsulfonyl)-L-phenylalanyl-N-<1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl>-3-<2-<<(phenylmethoxy)carbonyl>amino>-4-thiazolyl>-L-alaninamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm00092a006

Reference yield:

: 122621-77-6
(2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

: 135727-10-5
(4-{(R)-2-((1S,2R,3S)-1-Cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-2-[(S)-2-(morpholine-4-sulfonylamino)-3-phenyl-propionylamino]-ethyl}-thiazol-2-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

2: HCl (gas) / CH₂Cl₂; methanol / Ambient temperature

3: N-hydroxybenzotriazole (HOBT), dicyclohexylcarbodiimide (DCC) / dimethylformamide / 0 - 20 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a006