(4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic

Base Information

Chemical Name:(4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic
CAS No.:220440-54-0
Molecular Formula:C₄₅H₆₃N₇O₁₃
Molecular Weight:910.034
Hs Code.:

(4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic

Synonyms:

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Chemical Property of (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic

Chemical Property:

Density:1.3g/cm³

Purity/Quality:

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MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic

There total 3 articles about (4R)-4-{[(2S)-2-(acetylamino)-3-carboxypropanoyl]amino}-5-{[(2S,3S)-1-({(2S)-1-[(2S,4R)-4-(benzyloxy)-2-({2-[(benzyloxy)carbonyl]-2-propylhydrazinyl}carbonyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}amino)-3-methyl-1-oxopentan-2-yl]amino}-5-oxopentanoic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112383-15-0
α-azanorvaline benzyl ester hydrochloride

: 220440-54-0
(R)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-((1S,2S)-1-{(S)-1-[(2S,4R)-4-benzyloxy-2-(N'-benzyloxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-butylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: TBTU; i-Pr₂NEt / dimethylformamide / 16 h / 20 °C

2: 56 mg / TFA / 1.5 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm049864b

Reference yield:

: C₄₀H₆₅N₅O₁₂Si₂

: 220440-54-0
(R)-4-((S)-2-Acetylamino-3-carboxy-propionylamino)-4-((1S,2S)-1-{(S)-1-[(2S,4R)-4-benzyloxy-2-(N'-benzyloxycarbonyl-N'-propyl-hydrazinocarbonyl)-pyrrolidine-1-carbonyl]-2-methyl-propylcarbamoyl}-2-methyl-butylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: TBTU; i-Pr₂NEt / dimethylformamide / 16 h / 20 °C

2: 56 mg / TFA / 1.5 h

With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm049864b