N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide

Base Information

Chemical Name:N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide
CAS No.:157584-43-5
Molecular Formula:C₁₅H₁₁ClF₃NO
Molecular Weight:313.707
Hs Code.:
DSSTox Substance ID:DTXSID601185702

Synonyms:DTXSID601185702;N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide;157584-43-5

Suppliers and Price of N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:313.0481262
Heavy Atom Count:21
Complexity:347

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CN(C2=CC=C(C=C2)Cl)C(=O)C(F)(F)F

Technology Process of N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide

There total 1 articles about N-(4-Chlorophenyl)-2,2,2-trifluoro-N-(phenylmethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2948-37-0
N-(4-chlorophenyl)benzylamine

: 407-25-0
trifluoroacetic anhydride

: 157584-43-5
N-Benzyl-N-(4-chloro-phenyl)-2,2,2-trifluoro-acetamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)76719-0

Reference yield: 98.0%

: 157584-43-5
N-Benzyl-N-(4-chloro-phenyl)-2,2,2-trifluoro-acetamide

: 157584-51-5
N-Benzyl-N-(4-chloro-phenyl)-2,2,2-trifluoro-thioacetamide

Guidance literature:: With Lawessons reagent; In toluene; at 100 ℃; for 12h;
DOI:10.1016/S0040-4039(00)76719-0

Reference yield:

: 157584-43-5
N-Benzyl-N-(4-chloro-phenyl)-2,2,2-trifluoro-acetamide

: Benzyl-(4-chloro-phenyl)-pentafluoroethyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / 2 / toluene / 12 h / 100 °C

2: 80 percent / nBu₄NH₂F₃, NBS / CH₂Cl₂ / 0.5 h / 0 - 22 °C

With Lawessons reagent; N-Bromosuccinimide; tetra-n-butylammonium dihydrogen trifluoride; In dichloromethane; toluene;
DOI:10.1016/S0040-4039(00)76719-0