Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)-

Base Information

Chemical Name:Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)-
CAS No.:852948-13-1
Molecular Formula:C₂₈H₃₂ClO₅P
Molecular Weight:514.986
Hs Code.:
UNII:3Z11398FNQ
ChEMBL ID:CHEMBL457748
DSSTox Substance ID:DTXSID501005783
Metabolomics Workbench ID:155302

Synonyms:2-((3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phenoxy)methyl)-4-(3-chlorophenyl)-2-oxido(1,3,2)dioxaphosphonane;MB 07811;MB-07811;MB07811;VK2809

Suppliers and Price of Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 7 raw suppliers

Chemical Property of Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)-

Chemical Property:

XLogP3:6.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:514.1675888
Heavy Atom Count:35
Complexity:708

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OCP3(=O)OCCC(O3)C4=CC(=CC=C4)Cl
Isomeric SMILES:CC1=CC(=CC(=C1CC2=CC(=C(C=C2)O)C(C)C)C)OC[P@@]3(=O)OCC[C@H](O3)C4=CC(=CC=C4)Cl
Recent ClinicalTrials:A Study to Assess the Efficacy and Safety of VK2809 for 52 Weeks in Subjects With Biopsy Proven NASH
Recent EU Clinical Trials:VK2809 A PHASE 2B, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO ASSESS THE EFFICACY, SAFETY, AND TOLERABILITY OF VK2809 ADMINISTERED FOR 52 WEEKS FOLLOWED BY A 4-WEEK OFF-DRUG PHASE IN SUBJECTS WITH BIOPSY PROVEN NON-ALCOHOLIC STEATOHEPATITIS WITH FIBROSIS

Technology Process of Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)-

There total 28 articles about Phenol, 4-((4-(((2R,4S)-4-(3-chlorophenyl)-2-oxido-1,3,2-dioxaphosphorinan-2-yl)methoxy)-2,6-dimethylphenyl)methyl)-2-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 852950-33-5
cis (S)-2-[(4-(4'-acetoxy-3'-iso-propylbenzyl)-3,5-dimethylphenoxy)methyl]-4-(3-chlorophenyl)-2-oxo-2λ5-[1,3,2]-dioxaphosphonane

: 852948-13-1
[14C]-MB07811

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 3.5h;

Reference yield: 75.0%

: C₁₉H₂₃Cl₂O₃P

: 625095-57-0
(S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol

: 852948-13-1
[14C]-MB07811

Guidance literature:: (S)-(-)-1-(3-Chlorophenyl)-1,3-propanediol; With titanium tetrachloride; triethylamine; In dichloromethane; at -15 - -5 ℃;

C₁₉H₂₃Cl₂O₃P; In dichloromethane; at -60 - -40 ℃;