4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide

Base Information

• Chemical Name: 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide
• CAS No.: 1338575-89-5
• Molecular Formula: C₂₆H₂₃N₃O₈S₂
• Molecular Weight: 569.616

Synonyms:4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide

Chemical Property of 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide

There total 2 articles about 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

tert-butyl 4-(1-tosyl-1H-indol-3-yl)pent-4-enoate (1338575-78-2) + p-nitrobenzenesulfonamide (6325-93-5) → 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide (1338575-89-5)

Guidance literature:

tert-butyl 4-(1-tosyl-1H-indol-3-yl)pent-4-enoate; With tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; In acetonitrile; at 20 ℃; for 0.166667h; Molecular sieve; Inert atmosphere;

p-nitrobenzenesulfonamide; With iodosylbenzene; In acetonitrile; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/ol202436a

Reference yield:

4-bromo-4-pentenoic acid tert-butyl ester (92975-38-7) → 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide (1338575-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride / ethanol; toluene / 3 h / 100 °C / Inert atmosphere

2.1: tetrakis(actonitrile)copper(I) hexafluorophosphate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / acetonitrile / 0.17 h / 20 °C / Molecular sieve; Inert atmosphere

2.2: 48 h / 20 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrakis(actonitrile)copper(I) hexafluorophosphate; sodium carbonate; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; lithium chloride; In ethanol; toluene; acetonitrile; 1.1: Suzuki coupling;

DOI:10.1021/ol202436a

Reference yield:

4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide (1338575-89-5) → 3a'-bromo-1'-((4-nitrophenyl)sulfonyl)-8'-tosyl-2',3a',8',8a'-tetrahydro-1'H,3H-spiro[furan-2,3'-pyrrolo[2,3-b]indol]-5(4H)-one + 3a'-bromo-1'-((4-nitrophenyl)sulfonyl)-8'-tosyl-2',3a',8',8a'-tetrahydro-1'H,3H-spiro[furan-2,3'-pyrrolo[2,3-b]indol]-5(4H)-one

Guidance literature:

With N-Bromosuccinimide; In tetrachloromethane; for 5h; Reflux;

DOI:10.1021/ol202436a

upstream raw materials:

tert-butyl 4-(1-tosyl-1H-indol-3-yl)pent-4-enoate

p-nitrobenzenesulfonamide

4-bromo-4-pentenoic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1338575-89-5 4-nitro-N-((5-oxo-2-(1-tosyl-1H-indol-3-yl)tetrahydrofuran-2-yl)methyl)benzenesulfonamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send