((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Base Information

Chemical Name:((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol
CAS No.:1283146-08-6
Molecular Formula:C₂₀H₂₂F₃NO
Molecular Weight:349.396
Hs Code.:

Synonyms:((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

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Technology Process of ((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

There total 5 articles about ((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1283147-19-2
1-(4-iodobenzyl)-2-methylbenzene

: 1283146-07-5
((2S,4S)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol hydrochloride

: 1283146-08-6
((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:: With copper(l) iodide; sodium hydroxide; In isopropyl alcohol; at 90 ℃; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.jmedchem.6b01559

Reference yield: 61.6%

: 1283146-08-6
((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:

Reference yield:

: C₁₆H₂₄F₃NO₆

: 1283146-08-6
((2S,4S)-1-(4-(2-methylbenzyl)phenyl)-4-(trifluoromethyl)pyrrolidin-2-yl)methanol

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / water / 0 - 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C / Inert atmosphere

3: copper(l) iodide; sodium hydroxide / isopropyl alcohol / 90 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; sodium tetrahydroborate; copper(l) iodide; sodium hydroxide; In 1,4-dioxane; water; isopropyl alcohol;
DOI:10.1021/acs.jmedchem.6b01559