1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

Base Information

Chemical Name:1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide
CAS No.:1613253-82-9
Molecular Formula:C₃₂H₃₆N₆O₇
Molecular Weight:616.674
Hs Code.:

Synonyms:1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

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Chemical Property of 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

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Technology Process of 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

There total 6 articles about 1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1613134-41-0
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid

: 1598432-47-3
((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-carbamic acid tert-butyl ester

: 1613253-82-9
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

Guidance literature:: ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3]triazole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: (S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyric acid

: 1613253-82-9
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.2: 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1-(2-amino-ethyl)-1H-[1,2,3]triazole-4-carboxylic acid methyl ester hydrochloride

: 1613253-82-9
1-[2-(2,3,4-trimethoxy-benzoylamino)-ethyl]-1H-[1,2,3] triazole-4-carboxylic acid ((S)-1-benzyl-2-benzylcarbamoyl-2-hydroxy-ethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl acetamide / 1 h / 0 °C

1.2: 20 °C

2.1: sodium hydroxide; water / methanol / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.2: 0 - 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl acetamide;