3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

Base Information

Chemical Name:3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid
CAS No.:1208315-51-8
Molecular Formula:C₂₃H₂₂N₄O₂
Molecular Weight:386.453
Hs Code.:

Synonyms:3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

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Chemical Property of 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

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Technology Process of 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

There total 7 articles about 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1208315-24-5
3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrole -2-yl)propionic acid

: 1208315-51-8
3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: With sodium hypochlorite; water; sodium hydroxide; In water; at 0 - 75 ℃; for 2.5h;
DOI:10.1016/j.bmcl.2012.01.047

Reference yield:

: ethyl 3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-carbamoyl-2-methylphenyl)-1H-pyrrol-2-yl)propanoate

: 1208315-51-8
3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate; water / tetrahydrofuran / 5 h / 20 °C

2: sodium hypochlorite; sodium hydroxide / water / 2.5 h / 0 - 75 °C

With sodium hypochlorite; lithium hydroxide monohydrate; water; sodium hydroxide; In tetrahydrofuran; water;

Reference yield:

: 98-01-1
furfural

: 1208315-51-8
3-(5-(4-(1H-imidazol-1-yl)phenyl)-1-(4-amino-2-methylphenyl)-1H-pyrrol-2-yl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium methylate / 20 °C

2: hydrogen bromide / water; ethanol / 8 h / Reflux

3: toluene-4-sulfonic acid / ethanol / Reflux

4: L-proline; copper(l) iodide; potassium carbonate / dimethyl sulfoxide / 100 °C / Inert atmosphere

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 5 h / 20 °C

6: sodium hypochlorite; sodium hydroxide / water / 2.5 h / 0 - 75 °C

With methanol; sodium hypochlorite; copper(l) iodide; lithium hydroxide monohydrate; water; hydrogen bromide; sodium methylate; potassium carbonate; toluene-4-sulfonic acid; L-proline; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;