(Aminomethyl)phenylphosphinic acid

Base Information

• Chemical Name: (Aminomethyl)phenylphosphinic acid
• CAS No.: 15901-08-3
• Molecular Formula: C7H10 N O2 P
• Molecular Weight: 171.1336
• NSC Number: 167577
• DSSTox Substance ID: DTXSID90304847
• Nikkaji Number: J669.790I
• Wikidata: Q82051107
• Mol file: 15901-08-3.mol

Synonyms:15901-08-3;(Aminomethyl)phenylphosphinic acid;NSC167577;SCHEMBL5668125;DTXSID90304847;(aminomethyl)(phenyl)phosphinic acid;NSC-167577

Chemical Property of (Aminomethyl)phenylphosphinic acid

Chemical Property:

• Vapor Pressure: 9.28E-08mmHg at 25°C
• Boiling Point: 418.7°Cat760mmHg
• Flash Point: 207°C
• Density: 1.27g/cm³
• XLogP3: -2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 171.04491556
• Heavy Atom Count: 11
• Complexity: 166

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(=O)(CN)O

Technology Process of (Aminomethyl)phenylphosphinic acid

There total 2 articles about (Aminomethyl)phenylphosphinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-(hydroxymethyl)benzamide (6282-02-6) + Dichlorophenylphosphine (644-97-3) → Aminomethyl-phenyl-phosphinsaeure (15901-08-3)

Guidance literature:

With hydrogenchloride; In acetic acid; 1.) 60 min, 25 deg C then reflux, 60 min; 2.) reflux;

DOI:10.1039/DT9960002685

Reference yield:

→ Aminomethyl-phenyl-phosphinsaeure (15901-08-3)

Guidance literature:

Phthalimidomethyl-phenyl-phosphinsaeure-methylester, 48percentig HBr in EtOH;

DOI:10.1021/jo01045a516

Reference yield: 78.0%

Aminomethyl-phenyl-phosphinsaeure (15901-08-3) + cobalt(II) perchlorate hexahydrate → Co(2+)*2H2NCH2P(C6H5)O2(1-)*4.5H2O = [Co(H2NCH2P(C6H5)O2)2]*4.5H2O

Guidance literature:

With aq. NaOH; In water; addn. of the ligand in H2O to the Co salt in H2O with stirring, slow addn. of 1 % aq. NaOH to pH ca. 7, readjusting the pH several times to 7, standing (room temp., overnight); elem. anal.;

DOI:10.1039/DT9960002685

upstream raw materials:

N-(hydroxymethyl)benzamide

Dichlorophenylphosphine

Downstream raw materials:

[Cu(H₂NCH₂P(C₆H₅)O₂)2]2

Refernces