tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate
CAS No.:1610698-30-0
Molecular Formula:C₃₀H₃₅N₅O₃
Molecular Weight:513.64
Hs Code.:

Synonyms:tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

There total 5 articles about tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610698-29-7
tert-butyl (R)-3-(4-amino-5-(4-phenoxyphenyl)-6-(prop-1-en-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

: 1610698-30-0
tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; at 65 ℃;

Reference yield:

: 1610697-81-8
tert-butyl (R)-3-(4-amino-6-bromo-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

: 1610698-30-0
tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / 65 °C

With palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; water;

Reference yield:

: 1272668-51-5
(R)-3-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1610698-30-0
tert-butyl (R)-3-(4-amino-6-isopropyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonium hydroxide / 1,4-dioxane / 0.83 h / 120 °C / Microwave irradiation; Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

4: sodium carbonate / 1,4-dioxane; water / 80 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / 65 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; N-Bromosuccinimide; palladium 10% on activated carbon; hydrogen; sodium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water;