dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

Base Information

Chemical Name:dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate
CAS No.:1332721-77-3
Molecular Formula:C₂₂H₂₉NO₆
Molecular Weight:403.475
Hs Code.:

Synonyms:dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

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Chemical Property of dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

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Technology Process of dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

There total 3 articles about dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 103218-10-6
dimethyl 2-(methylamino)malonate

: C₁₆H₁₉ClO₂

: 1332721-77-3
dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

Guidance literature:: In toluene; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol202306d

Reference yield:

: 955959-44-1
((2R,6R)-7-benzyloxy)-2,6-dimethylhept-3-yn-1-ol

: 1332721-77-3
dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

Guidance literature:: Multi-step reaction with 3 steps

1: Jones reagent / acetone / 4 h / 0 °C / Inert atmosphere

2: thionyl chloride / toluene / 10 h / 0 - 20 °C / Inert atmosphere

3: toluene / 2 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; thionyl chloride; In acetone; toluene; 1: Jones oxidation;
DOI:10.1021/ol202306d

Reference yield:

: 1332721-92-2
C₁₆H₂₀O₃

: 1332721-77-3
dimethyl 2-((2R,6R)-7-(benzyloxy)-N,2,6-trimethylhept-3-ynamido)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / toluene / 10 h / 0 - 20 °C / Inert atmosphere

2: toluene / 2 h / 0 - 20 °C / Inert atmosphere

With thionyl chloride; In toluene;
DOI:10.1021/ol202306d