tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate
CAS No.:439691-97-1
Molecular Formula:C₁₇H₂₃NO₄
Molecular Weight:305.374
Hs Code.:

Synonyms:tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

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Chemical Property of tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

There total 4 articles about tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5798-75-4
Ethyl 4-bromobenzoate

: 1064194-10-0
3-bromo-azetidine-1-carboxylic acid tert-butyl ester

: 439691-97-1
tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: With potassium hexafluorophosphate; bis(1,3-bis((4-methyl-2-pyridyl)imino)isoindolinato)nickel(II); C₂₂H₁₉N₅NiO₂; In N,N-dimethyl acetamide; at 20 ℃; Inert atmosphere; Electrolysis; Sealed tube;
DOI:10.1021/jacs.0c01475

Reference yield: 68.0%

: 51934-41-9
4-iodobenzoic acid ethyl ester

: 254454-54-1
tert-butyl-3-iodoazetidine-1-carboxylate

: 439691-97-1
tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: tert-butyl-3-iodoazetidine-1-carboxylate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 0.75h; Inert atmosphere;

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; In tetrahydrofuran; ethylene dibromide; at 20 ℃; for 0.25h; Inert atmosphere;

4-iodobenzoic acid ethyl ester; In tetrahydrofuran; ethylene dibromide; at 20 - 65 ℃; Inert atmosphere;

Reference yield:

: 141699-55-0
tert-butyl 3-hydroxyazetidine-1-carboxylate

: 439691-97-1
tert-butyl 3-(4-(ethoxycarbonyl)phenyl)azetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

2.1: potassium iodide / dimethyl sulfoxide / 2 h / 140 °C / Inert atmosphere

3.1: zinc; chloro-trimethyl-silane / tetrahydrofuran; ethylene dibromide / 0.75 h / 20 °C / Inert atmosphere

3.2: 0.25 h / 20 °C / Inert atmosphere

3.3: 20 - 65 °C / Inert atmosphere

With chloro-trimethyl-silane; triethylamine; potassium iodide; zinc; In tetrahydrofuran; dimethyl sulfoxide; ethylene dibromide;