2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Base Information

Chemical Name:2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide
CAS No.:147267-22-9
Molecular Formula:C₃₁H₃₄F₃N₃O₆
Molecular Weight:601.623
Hs Code.:

Synonyms:2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Chemical Property of 2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

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Technology Process of 2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

There total 11 articles about 2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147283-31-6
{6-(3-tert-Butoxy-phenyl)-2-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester

: 147267-22-9
2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: With dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dimethyl sulfoxide; toluene;
DOI:10.1021/jm00046a015

Reference yield:

: 106746-09-2
3(RS)-amino-1,1,1-trifluoro-2(RS)-hydroxy-4-methylpentane hydrochloride

: 147267-22-9
2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methyl-morpholine / tetrahydrofuran / 12 h

2: 2,6-dimethylpyridine / dichloromethane / 12 h

3: sodium iodide / acetone / 12 h / Ambient temperature

4: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

5: tetrabutyl ammonium fluoride / tetrahydrofuran

6: dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dimethyl sulfoxide; toluene

With 4-methyl-morpholine; 2,6-dimethylpyridine; dichloro-acetic acid; tetrabutyl ammonium fluoride; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm00046a015

Reference yield:

: 147269-04-3
2-chloro-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide

: 147267-22-9
2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 2,6-dimethylpyridine / dichloromethane / 12 h

2: sodium iodide / acetone / 12 h / Ambient temperature

3: sodium hydride / 1.) DMF, RT, 2.) DMF, RT

4: tetrabutyl ammonium fluoride / tetrahydrofuran

5: dichloro-acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dimethyl sulfoxide; toluene

With 2,6-dimethylpyridine; dichloro-acetic acid; tetrabutyl ammonium fluoride; sodium hydride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; sodium iodide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; acetone; toluene;
DOI:10.1021/jm00046a015