methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate
• CAS No.: 1154391-33-9
• Molecular Formula: C₁₆H₁₃N₃O₂
• Molecular Weight: 279.298
• Mol file: 1154391-33-9.mol

Synonyms:methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate

Chemical Property of methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate

There total 2 articles about methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.9%

methyl 2,4-dioxo-4-(pyridin-4-yl)butanoate (374063-91-9) + phenylhydrazine hydrochloride (59-88-1) → methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate (1154391-33-9)

Guidance literature:

In methanol; for 5h; Reflux;

DOI:10.2174/15734064113096660044

Reference yield:

methyl (4-pyridyl) ketone (1122-54-9) → methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate (1154391-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium methylate; sodium / methanol; diethyl ether / 1 h / Cooling with ice

2: methanol / 5 h / Reflux

With sodium methylate; sodium; In methanol; diethyl ether;

DOI:10.2174/15734064113096660044

Reference yield: 95.2%

methyl 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylate (1154391-33-9) → 1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid (144252-14-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Reflux;

DOI:10.2174/15734064113096660044

upstream raw materials:

methyl 2,4-dioxo-4-(pyridin-4-yl)butanoate

phenylhydrazine hydrochloride

methyl (4-pyridyl) ketone

Downstream raw materials:

1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carboxylic acid

1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide

5-[1-phenyl-5-(pyridin-4-yl)-1H-pyrazol-3-yl]-1,3,4-oxadiazole-2-thiol

N'-benzylidene-1-phenyl-5-(pyridin-4-yl)-1H-pyrazole-3-carbohydrazide