Technology Process of 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-mannitol
There total 7 articles about 1,5-anhydro-2,3-dideoxy-6-O-(4,4'-dimethoxytrityl)-3-fluoro-2-(thymin-1-yl)-D-mannitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 1 h / 75 °C
2: pyridine / 1.5 h / 0 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 1.5 h / 20 °C
4: 20% palladium hydroxide on charcoal; hydrogen / methanol / 6 h
5: pyridine / 0 - 20 °C
With
pyridine; 20% palladium hydroxide on charcoal; hydrogen; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja207086x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: pyridine / 1.5 h / 0 °C
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 1.5 h / 20 °C
3: 20% palladium hydroxide on charcoal; hydrogen / methanol / 6 h
4: pyridine / 0 - 20 °C
With
pyridine; 20% palladium hydroxide on charcoal; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dimethyl sulfoxide;
DOI:10.1021/ja207086x
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / methanol / 1.5 h / 20 °C
2: toluene-4-sulfonic acid / N,N-dimethyl-formamide / 1 h / 75 °C
3: pyridine / 1.5 h / 0 °C
4: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 1.5 h / 20 °C
5: 20% palladium hydroxide on charcoal; hydrogen / methanol / 6 h
6: pyridine / 0 - 20 °C
With
pyridine; 20% palladium hydroxide on charcoal; hydrogen; potassium carbonate; toluene-4-sulfonic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja207086x
