1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

Base Information

Chemical Name:1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea
CAS No.:641611-26-9
Molecular Formula:C₁₉H₂₇N₃O₆S
Molecular Weight:425.506
Hs Code.:

Synonyms:1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

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Chemical Property of 1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

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Technology Process of 1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

There total 1 articles about 1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 107819-90-9
1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 641611-26-9
1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

Guidance literature:: 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea; With sodium hydride; In N,N-dimethyl-formamide; for 1h; cooling;

1-bromomethyl-4-nitro-benzene; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm0309203

Reference yield: 43.0%

: 126898-43-9
5'-amino-17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-3,14-dihydroxyindolo[2',3':6,7]morphinan

: 641611-26-9
1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

: 641611-46-3
17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-5'-bis-tert-butoxycarbonyl-(N'-4-nitrobenzyl)guanidinyl-3,14-dihydroxyindolo[2',3':6,7]morphinan

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 24h;
DOI:10.1021/jm0309203

Reference yield:

: 641611-26-9
1,3-bis-tert-butoxycarbonyl-1-(4'-nitrobenzyl)-2-methyl-2-thiopseudourea

: 641611-48-5
17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-5'-bis-tert-butoxycarbonyl-(N'-4-aminobenzyl)guanidinyl-3,14-dihydroxyindolo[2',3':6,7]morphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 43 percent / HgCl₂; Et₃N / dimethylformamide / 24 h / 50 °C

2: 63 percent / cyclohexene; Et₃N / Raney Ni / methanol / 5 h / 20 °C

With triethylamine; mercury dichloride; cyclohexene; nickel; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm0309203