3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

Base Information

Chemical Name:3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine
CAS No.:1297395-57-3
Molecular Formula:C₉H₆F₃N₃O₃
Molecular Weight:261.16
Hs Code.:

Synonyms:3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

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Chemical Property of 3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

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Technology Process of 3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

There total 6 articles about 3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.8%

: 891501-19-2
3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine

: 1297395-57-3
3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

Guidance literature:: With nitric acid; In acetic anhydride; at 20 ℃; Cooling with ice;
DOI:10.1016/j.bmcl.2011.01.118

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 1297395-57-3
3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 6 steps

1.1: magnesium / tetrahydrofuran; ethylene dibromide / 2 h / Inert atmosphere; Reflux

1.2: 2 h / Inert atmosphere; Reflux

2.1: hydroxylamine hydrochloride / pyridine; ethanol / 12 h / 60 °C / Inert atmosphere

3.1: pyridine / 1 h / Inert atmosphere; Cooling with ice

4.1: ammonia / -78 - 20 °C

5.1: silver(l) oxide / diethyl ether / 12 h / 20 °C / Inert atmosphere

6.1: nitric acid / acetic anhydride / 20 °C / Cooling with ice

With hydroxylamine hydrochloride; ammonia; nitric acid; magnesium; silver(l) oxide; In tetrahydrofuran; pyridine; diethyl ether; ethanol; acetic anhydride; ethylene dibromide;
DOI:10.1016/j.bmcl.2011.01.118

Reference yield:

: 3-(4-Methoxyphenyl)-3-(trifluoromethyl)diaziridine

: 1297395-57-3
3-(4-methoxy-3-nitrophenyl)-3-trifluoromethyl-3H-diazirine

Guidance literature:: Multi-step reaction with 2 steps

1: silver(l) oxide / diethyl ether / 12 h / 20 °C / Inert atmosphere

2: nitric acid / acetic anhydride / 20 °C / Cooling with ice

With nitric acid; silver(l) oxide; In diethyl ether; acetic anhydride;
DOI:10.1016/j.bmcl.2011.01.118