allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate

Base Information

• Chemical Name: allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate
• CAS No.: 910213-98-8
• Molecular Formula: C₄₄H₄₉N₄O₁₃PS
• Molecular Weight: 904.932

Synonyms:allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate

Chemical Property of allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate

There total 6 articles about allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3'-O-(acetyl)-2'-deoxythymidin-5'-yl allyl (SP)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl phosphorothioate (910213-84-2) → allyl (SP)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate (910213-98-8)

Guidance literature:

With sodium methylate; In methanol; at 25 ℃; for 4h;

DOI:10.1002/ejoc.200600155

Reference yield:

allyl (RP)-2'-deoxythymidine 3',5'-cyclic phosphorothioate (910213-57-9) → allyl (SP)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate (910213-98-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 83 percent / sodium methoxide / 24 h / 25 °C

2.1: 91 percent / dimethylformamide; pyridine / 7 h / 25 °C

3.1: various solvent(s) / 24 h / 35 °C

3.2: 92 percent / CH₂Cl₂; H₂O

4.1: 54 percent / triphenylphosphane; DEAD / tetrahydrofuran; toluene / 3 h / 60 °C

5.1: 88 percent / sodium methoxide / methanol / 4 h / 25 °C

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; toluene; 4.1: Mitsunobu reaction;

DOI:10.1002/ejoc.200600155

Reference yield:

allyl methyl (RP)-2'-deoxythymidin-3'-yl phosphorothioate (910213-61-5) → allyl (SP)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate (910213-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 91 percent / dimethylformamide; pyridine / 7 h / 25 °C

2.1: various solvent(s) / 24 h / 35 °C

2.2: 92 percent / CH₂Cl₂; H₂O

3.1: 54 percent / triphenylphosphane; DEAD / tetrahydrofuran; toluene / 3 h / 60 °C

4.1: 88 percent / sodium methoxide / methanol / 4 h / 25 °C

With sodium methylate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; toluene; 3.1: Mitsunobu reaction;

DOI:10.1002/ejoc.200600155

upstream raw materials:

3'-O-(acetyl)-2'-deoxythymidin-5'-yl allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl phosphorothioate

allyl (R_P)-2'-deoxythymidine 3',5'-cyclic phosphorothioate

allyl methyl (R_P)-2'-deoxythymidin-3'-yl phosphorothioate

allyl methyl (R_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl phosphorothioate

Downstream raw materials:

C₅₃H₆₇N₅O₁₄P₂S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 910213-98-8 allyl (S_P)-2'-deoxy-5'-O-(p,p'-dimethoxytrityl)thymidin-3'-yl 2'-deoxythymidin-5'-yl phosphorothioate

Send

Send

Metric Ton KG G Pound L ML

Send

Send