4-Quinolineacetic acid, Methyl ester

Base Information

• Chemical Name: 4-Quinolineacetic acid, Methyl ester
• CAS No.: 158265-22-6
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.225
• Mol file: 158265-22-6.mol

Synonyms:quinoline-4-acetic acid methyl ester

Chemical Property of 4-Quinolineacetic acid, Methyl ester

Chemical Property:

• Boiling Point: 332.2±17.0 °C(Predicted)
• PKA: 4.98±0.13(Predicted)
• Density: 1.186±0.06 g/cm3(Predicted)

Purity/Quality:

Methylquinoline-4-acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Quinolineacetic acid, Methyl ester

There total 4 articles about 4-Quinolineacetic acid, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(2-chloroquinolin-4-yl)acetic acid methyl ester (158265-19-1) → quinoline-4-acetic acid methyl ester (158265-22-6)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; for 8h;

Reference yield:

2-(2-oxo-1,2-dihydroquinoline-4-yl)acetic acid (21298-80-6) → quinoline-4-acetic acid methyl ester (158265-22-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / HCl (gas.) / Ambient temperature

2: 83 percent / POCl₃ / 2 h / 80 °C

3: 89 percent / H₂, Et₃N / 10percent Pd/C / methanol / 8 h

With hydrogenchloride; hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol;

Reference yield:

(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid methylester (103702-23-4) → quinoline-4-acetic acid methyl ester (158265-22-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 83 percent / POCl₃ / 2 h / 80 °C

2: 89 percent / H₂, Et₃N / 10percent Pd/C / methanol / 8 h

With hydrogen; triethylamine; trichlorophosphate; palladium on activated charcoal; In methanol;

upstream raw materials:

2-(2-chloroquinolin-4-yl)acetic acid methyl ester

2-(2-oxo-1,2-dihydroquinoline-4-yl)acetic acid

(2-oxo-1,2-dihydroquinolin-4-yl)acetic acid methylester

1-acetyl-4-dicyanomethylene-2-methoxy-1,4-dihydroquinoline

Refernces