2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Base Information

Chemical Name:2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate
CAS No.:1244040-64-9
Molecular Formula:C₁₈H₁₈N₆O₅
Molecular Weight:398.378
Hs Code.:

Synonyms:2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Suppliers and Price of 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate ≥90%
25mg
$ 575.00

Sigma-Aldrich
2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate ≥90%
5mg
$ 197.00

Sigma-Aldrich
2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate ≥90%
1mg
$ 59.90

Total 6 raw suppliers

Chemical Property of 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2,5-Dioxo-1-pyrrolidinyl 5-[4-(1,2,4,5-tetrazin-3-yl)benzylamino]-5-oxopentanoate ≥90% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Succinimidyl ester functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. Succinimidyl ester will react with amines for small molecule, biomolecule or surface modification. Tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.

Technology Process of 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

There total 7 articles about 2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74124-79-1
di(succinimido) carbonate

: 1225146-53-1
5-(4-(1,2,4,5-tetrazin-3-yl)benzylamino)-5-oxopentanoic acid

: 1244040-64-9
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Guidance literature:: With pyridine;

Reference yield:

: 108-55-4
glutaric anhydride,

: 74124-79-1
di(succinimido) carbonate

: (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetate

: 1244040-64-9
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Guidance literature:: glutaric anhydride,; (4-(1,2,4,5-tetrazin-3-yl)phenyl)methanamine trifluoroacetate; With triethylamine; In dichloromethane; at 20 ℃; for 1h;

di(succinimido) carbonate; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1039/c3cc49530b

Reference yield:

: 15996-76-6
4-cyanobenzylamine hydrochloride

: 1244040-64-9
2,5-dioxopyrrolidin-1-yl 5-((4-(1,2,4,5-tetrazin-3-yl)benzyl)amino)-5-oxopentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfur; hydrazine / 20 h

1.2: 0.25 h / Cooling with ice

2.1: triethylamine / N,N-dimethyl-formamide / 3 h

3.1: pyridine

With pyridine; sulfur; triethylamine; hydrazine; In N,N-dimethyl-formamide;