11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

Base Information

Chemical Name:11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one
CAS No.:1421037-50-4
Molecular Formula:C₂₉H₃₂F₂O₃
Molecular Weight:466.568
Hs Code.:

Synonyms:11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

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Chemical Property of 11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

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Technology Process of 11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

There total 4 articles about 11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 420-90-6
3-bromo-3,3-difluropropene

: 1421036-64-7
3,3-ethylenedioxy-11β-{4'-[1',1'-(ethylenedioxy)-ethyl]phenyl}-estra-4,9-diene-17-one

: 1421037-50-4
11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

Guidance literature:: 3-bromo-3,3-difluropropene; 3,3-ethylenedioxy-11β-{4'-[1',1'-(ethylenedioxy)-ethyl]phenyl}-estra-4,9-diene-17-one; With n-butyllithium; In tetrahydrofuran; diethyl ether; pentane; at -100 - 20 ℃; for 4.5h;

With sulfuric acid; In methanol; water; at 0 - 20 ℃; for 2h;

Reference yield:

: C₃₃H₄₀F₂O₅

: 1421037-50-4
11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

Guidance literature:: With sulfuric acid; In methanol; water; at 20 ℃; for 2h;
DOI:10.1016/j.steroids.2013.04.003

Reference yield:

: 151424-85-0
3,3-ethylenedioxy-5α-hydroxy-11β-{4'-[1',1'-(ethylenedioxy)-ethyl]phenyl}-estr-9-ene-17-one

: 1421037-50-4
11β-(4'-acetylphenyl)-17β-hydroxy-17-(1,1-difluoroprop-2-enyl)-estra-4,9-diene-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; acetic anhydride / 30 h / 70 °C

2: n-butyllithium / tetrahydrofuran; diethyl ether; pentane / 4.5 h / -95 - 20 °C / Inert atmosphere

3: sulfuric acid / water; methanol / 2 h / 20 °C

With dmap; n-butyllithium; sulfuric acid; acetic anhydride; In tetrahydrofuran; methanol; diethyl ether; water; pentane;
DOI:10.1016/j.steroids.2013.04.003