Technology Process of N-(5-fluoropyridin-2-yl)-2-[(3,4-dimethoxyphenyl)oxymethyl]-2-phenylcyclopropanecarboxamide
There total 5 articles about N-(5-fluoropyridin-2-yl)-2-[(3,4-dimethoxyphenyl)oxymethyl]-2-phenylcyclopropanecarboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(3,4-Dimethoxyphenyl)oxymethyl-2-phenylcyclopropanecarboxylic acid;
With
triethylamine; trichloromethyl chloroformate;
In
tetrahydrofuran;
for 0.0833333h;
2-amino-5-fluoropyridine;
In
tetrahydrofuran;
at 10 - 35 ℃;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium amide / benzene / 3 h / 35 °C / Cooling with ice
1.2: 4 h / 35 °C / Cooling with ice
1.3: 16.5 h / Reflux
2.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 16.5 h / 10 - 35 °C
2.2: Cooling with ice
3.1: 1H-imidazole / N,N-dimethyl-formamide / 1.17 h / -15 °C
4.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 °C
5.1: potassium carbonate / N,N-dimethyl-formamide / 24.5 h / 70 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 35 °C
7.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
7.2: 0.25 h
8.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 2.5 h / 10 - 35 °C
9.1: triethylamine; trichloromethyl chloroformate / tetrahydrofuran / 0.08 h
9.2: 10 - 35 °C
With
1H-imidazole; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; sodium amide; carbon tetrabromide; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; triphenylphosphine; trichloromethyl chloroformate;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; benzene;
7.1: Swern Oxidation;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24.5 h / 70 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 10 - 35 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C
3.2: 0.25 h
4.1: 2-methyl-but-2-ene; sodium chlorite; sodium dihydrogenphosphate / water; acetone / 2.5 h / 10 - 35 °C
5.1: triethylamine; trichloromethyl chloroformate / tetrahydrofuran / 0.08 h
5.2: 10 - 35 °C
With
sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium carbonate; dimethyl sulfoxide; triethylamine; trichloromethyl chloroformate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone;
3.1: Swern Oxidation;
