dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate

Base Information

• Chemical Name: dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate
• CAS No.: 862457-41-8
• Molecular Formula: C₂₁H₁₆Cl₂O₆
• Molecular Weight: 435.26
• Mol file: 862457-41-8.mol

Synonyms:dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate

Chemical Property of dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate

There total 1 articles about dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Mucochloric acid (766-40-5) + malonic acid dibenzyl ester (15014-25-2) → dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate (862457-41-8)

Guidance literature:

indium acetylacetonate; In toluene; for 8h; Heating;

DOI:10.1021/jo050538t

Reference yield: 80.0%

dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate (862457-41-8) → 2-(3-chloro-5-oxo-5H-furan-2-ylidene)-malonic acid dibenzyl ester

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.07.123

Reference yield:

dibenzyl 2-(3,4-dichloro-5-oxo-2,5-dihydro-furan-2-yl)-malonate (862457-41-8) → 2-[3-(3,4-dimethoxy-phenyl)-5-oxo-5H-furan-2-ylidene]-malonic acid dibenzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / DABCO / tetrahydrofuran; various solvent(s) / 2 h / 20 °C

2: 81 percent / CsF; BnEt₃NCl / PdCl₂(PPh)3 / H₂O; toluene / Heating

With 1,4-diaza-bicyclo[2.2.2]octane; N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; PdCl₂(PPh)3; In tetrahydrofuran; water; toluene; 2: Suzuki coupling;

DOI:10.1016/j.tetlet.2005.07.123

upstream raw materials:

Mucochloric acid

malonic acid dibenzyl ester