(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Base Information

Chemical Name:(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol
CAS No.:147033-16-7
Molecular Formula:C₄₄H₆₄O₉
Molecular Weight:736.987
Hs Code.:

(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Synonyms:(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Suppliers and Price of (2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

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Chemical Property of (2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

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Technology Process of (2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

There total 19 articles about (2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 147033-15-6
(2E,4S,5R,6S,7R,8R,10R)-10-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-5,8-dihydroxy-7-(4-methoxybenzyloxy)-4,6,8-trimethyl-2-undecene

: 147033-16-7
(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Guidance literature:: With molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at -20 ℃;

Reference yield:

: 160625-13-8
(2S)-2-<(2R,4R,5S,6R)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-2-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>propanal

: 147033-16-7
(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / CH₂Cl₂ / 24 h / Ambient temperature

2: 99 percent / LiAlH₄ / diethyl ether / 6 h / Heating

4: 1.) 0.35M iPrMgBr; 2.) LiAlH₄ / 1.) THF, 30 min; 2.) THF, reflux, 6 h

5: 72 percent / 80percent NaH/white oil / dimethylformamide / 24 h

6: 1.) N-methylmorpholine N-oxide, 4percent OsO₄; 2.) NaIO₄ / 1.) tBuOH, acetone, r.t., 10 h; 2.) THF, water, 0 deg C, 3 h

7: 70 percent / petroleum ether / 72 h / 7500600 Torr

8: 82 percent / dichlorodicyanoquinone on molecular sieves / CH₂Cl₂ / 6 h / -20 °C

With sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; molecular sieve; isopropylmagnesium bromide; sodium hydride; 4-methylmorpholine N-oxide; white oil; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; Petroleum ether;

Reference yield:

: 147033-10-1
(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

: 147033-16-7
(2R,4R)-4-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-<(2R,4R,5S,6R)-2-<2-(4-methoxyphenyl)-5-methyl-4-<(2E,4S)-2-penten-4-yl>1,3-dioxan-2-yl>>-2-pentanol

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) O₃/O₂; 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to 0 deg C

2: 91 percent / CH₂Cl₂ / 24 h / Ambient temperature

3: 99 percent / LiAlH₄ / diethyl ether / 6 h / Heating

5: 1.) 0.35M iPrMgBr; 2.) LiAlH₄ / 1.) THF, 30 min; 2.) THF, reflux, 6 h

6: 72 percent / 80percent NaH/white oil / dimethylformamide / 24 h

7: 1.) N-methylmorpholine N-oxide, 4percent OsO₄; 2.) NaIO₄ / 1.) tBuOH, acetone, r.t., 10 h; 2.) THF, water, 0 deg C, 3 h

8: 70 percent / petroleum ether / 72 h / 7500600 Torr

9: 82 percent / dichlorodicyanoquinone on molecular sieves / CH₂Cl₂ / 6 h / -20 °C

With sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; molecular sieve; isopropylmagnesium bromide; oxygen; sodium hydride; ozone; 4-methylmorpholine N-oxide; triphenylphosphine; white oil; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; Petroleum ether;