[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

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Chemical Name:[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)
CAS No.:252353-69-8
Molecular Formula:C₂₄H₃₉N₃O₆
Molecular Weight:465.59
Hs Code.:

Synonyms:[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

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Chemical Property of [3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

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Technology Process of [3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

There total 9 articles about [3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: methyl <(phenoxycarbonyl)oxy>acetate

: 170367-72-3
3-[(4-aminobutyl)(phenylmethyl)amino-1(R)-methylpropyl]carbamic acid, 1,1-dimethylethyl ester

: 252353-69-8
[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

Guidance literature:: With triethylamine; In toluene; at 80 ℃; for 15h;
DOI:10.1021/jm991043x

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 252353-69-8
[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

Guidance literature:: Multi-step reaction with 9 steps

1: 82 percent / tetrahydrofuran / 1 h / 20 °C

2: 86 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C

4: 96 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

5: 98 percent / 3 Angstroem molecular sieves / diethyl ether / 20 h / 20 °C

6: 86 percent / NaBH₄ / ethanol / 3 h / 10 °C

7: 98 percent / KI; Na₂CO₃ / butan-1-ol / 20 h / Heating

8: 92 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

9: 90 percent / Et₃N / toluene / 15 h / 80 °C

With sodium tetrahydroborate; 3 A molecular sieve; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; nickel; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; toluene; butan-1-ol; 1: tert-Butyloxycarbonylation / 2: Mesylation / 3: Substitution / 4: Catalytic hydrogenation / 5: Condensation / 6: Reduction / 7: Alkylation / 8: Catalytic hydrogenation / 9: Condensation;
DOI:10.1021/jm991043x

Reference yield:

: 126301-16-4,149602-63-1,126301-17-5
(2R)-2-[(tert-butoxycarbonyl)amino]propyl methanesulfonate

: 252353-69-8
[3-[[4-(2,4-dioxo-3-oxazolidinyl)butyl](phynylmethyl)amino]-1-methylpropyl]carbamic acid, 1,1-dimethylethyl ester (R)

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / dimethylsulfoxide / 15 h / 40 - 45 °C

2: 96 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

3: 98 percent / 3 Angstroem molecular sieves / diethyl ether / 20 h / 20 °C

4: 86 percent / NaBH₄ / ethanol / 3 h / 10 °C

5: 98 percent / KI; Na₂CO₃ / butan-1-ol / 20 h / Heating

6: 92 percent / H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

7: 90 percent / Et₃N / toluene / 15 h / 80 °C

With sodium tetrahydroborate; 3 A molecular sieve; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; nickel; In diethyl ether; ethanol; dimethyl sulfoxide; toluene; butan-1-ol; 1: Substitution / 2: Catalytic hydrogenation / 3: Condensation / 4: Reduction / 5: Alkylation / 6: Catalytic hydrogenation / 7: Condensation;
DOI:10.1021/jm991043x