4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

Base Information

Chemical Name:4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide
CAS No.:868066-36-8
Molecular Formula:C₂₀H₂₃N₅OS
Molecular Weight:381.502
Hs Code.:

Synonyms:4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

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Chemical Property of 4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

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Technology Process of 4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

There total 4 articles about 4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 868066-36-8
4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

Guidance literature:

Reference yield:

: C₁₉H₂₅N₅OS

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 868066-36-8
4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 - 60 ℃; for 1.5h;
DOI:10.1016/j.bmc.2013.01.071

Reference yield:

: 1428556-50-6
benzyl 4-[4-(dimethylcarbamoyl)phenyl]-1,4-diazepane-1-carboxylate

: 868066-36-8
4-[4-(3-cyano-2-thioxo-1,2-dihydropyridin-4-yl)-1,4-diazepan-1-yl]-N,N-dimethyl benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 1 h / 20 °C

2: N,N-dimethyl-formamide / 0.5 h / 20 °C

3: N,N-dimethyl-formamide / 1.5 h / 20 - 60 °C

With palladium 10% on activated carbon; hydrogen; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2013.01.071