1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

Base Information

Chemical Name:1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde
CAS No.:1422129-36-9
Molecular Formula:C₁₆H₁₇F₆NO
Molecular Weight:353.307
Hs Code.:

Synonyms:1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

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Chemical Property of 1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

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Technology Process of 1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

There total 4 articles about 1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422129-35-8
{1-[2,4-bis(trifluoromethyl)benzyl]azepan-4-yl}methanol

: 1422129-36-9
1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine; at 20 ℃; for 1.5h;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1422129-36-9
1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium acetate / water / 20 °C

2.1: acetic acid / 1 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 60 °C / Cooling with ice

3.2: 3 h / 20 °C / Cooling with ice

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5.1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 1.5 h / 20 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; sodium acetate; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 90942-89-5
ethyl 4-(hydroxyimino)cyclohexane-1-carboxylate

: 1422129-36-9
1-[2,4-bis(trifluoromethyl)benzyl]azepane-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 1 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 60 °C / Cooling with ice

2.2: 3 h / 20 °C / Cooling with ice

3.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex; dimethyl sulfoxide / 1.5 h / 20 °C

With lithium aluminium tetrahydride; sulfur trioxide pyridine complex; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;