2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

Base Information

Chemical Name:2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine
CAS No.:725727-88-8
Molecular Formula:C₃₅H₃₉N₃O₉
Molecular Weight:645.709
Hs Code.:

Synonyms:2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

There total 5 articles about 2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 58632-95-4
2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

: 174221-86-4
5'-O-dimethoxytrityl-2'-amino-2'-deoxyuridine

: 725727-88-8
2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

Guidance literature:: With triethylamine; In 1,4-dioxane; at 40 ℃; for 16h;
DOI:10.1021/ol049366x

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 725727-88-8
2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP; pyridine / 16 h

2: Et₃N / 24 h / Heating

3: aq. NaOH / ethanol / 16 h / Heating

4: 94 percent / Et₃N / dioxane / 16 h / 40 °C

With pyridine; dmap; sodium hydroxide; triethylamine; In 1,4-dioxane; ethanol;
DOI:10.1021/ol049366x

Reference yield:

: 3736-77-4
2,2'-Anhydrouridine

: 725727-88-8
2'-deoxy-2'-(tert-butyloxycarbonyl)amino-5'-O-(4,4'-dimethoxytrityl)uridine

Guidance literature:: Multi-step reaction with 4 steps

1: DMAP; pyridine / 16 h

2: Et₃N / 24 h / Heating

3: aq. NaOH / ethanol / 16 h / Heating

4: 94 percent / Et₃N / dioxane / 16 h / 40 °C

With pyridine; dmap; sodium hydroxide; triethylamine; In 1,4-dioxane; ethanol;
DOI:10.1021/ol049366x