3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL

Base Information

• Chemical Name: 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL
• CAS No.: 73590-93-9
• Molecular Formula: C₈H₁₀ClN*ClH
• Molecular Weight: 192.088
• Hs Code.: 2933399090
• Mol file: 73590-93-9.mol

Synonyms:Pyridine,2-(chloromethyl)-3,5-dimethyl-, hydrochloride (9CI);2-(Chloromethyl)-3,5-dimethylpyridine hydrochloride

Chemical Property of 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL

Chemical Property:

• PSA: 12.89000
• LogP: 3.23920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

2-(Chloromethyl)-3,5-dimethylpyridineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Omeprazole metabolites

Technology Process of 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL

There total 5 articles about 3,5-DIMETHYL 2-CHLORMETHYL PYRIDINE.HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-hydroxymethyl-3,5-dimethylpyridine (202932-05-6) → 2-chloromethyl-3,5-dimethylpyridine hydrochloride (73590-93-9)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 - 5 ℃; for 1.75h;

DOI:10.1080/00397910801986192

Reference yield:

2,3,5-trimethyl-pyridine (695-98-7) → 2-chloromethyl-3,5-dimethylpyridine hydrochloride (73590-93-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / 30percent aq. H₂O₂, HOAc / 23 h / 90 °C

2: 100 percent / 110 °C

3: 75 percent / aq. NaOH / methanol / Heating

4: 79 percent / SOCl₂ / CH₂Cl₂ / 0 °C

With sodium hydroxide; thionyl chloride; dihydrogen peroxide; acetic acid; In methanol; dichloromethane;

DOI:10.1021/jm970165r

Reference yield:

2,3,5-trimethylpyridine 1-oxide (74409-42-0) → 2-chloromethyl-3,5-dimethylpyridine hydrochloride (73590-93-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / 110 °C

2: 75 percent / aq. NaOH / methanol / Heating

3: 79 percent / SOCl₂ / CH₂Cl₂ / 0 °C

With sodium hydroxide; thionyl chloride; In methanol; dichloromethane;

DOI:10.1021/jm970165r

upstream raw materials:

2-hydroxymethyl-3,5-dimethylpyridine

2,3,5-trimethyl-pyridine

2,3,5-trimethylpyridine 1-oxide

acetic acid 3,5-dimethylpyridin-2-ylmethyl ester

Downstream raw materials:

BIIB₀₂₁