2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

Base Information

Chemical Name:2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid
CAS No.:1168114-17-7
Molecular Formula:C₂₂H₂₃FN₂O₄
Molecular Weight:398.434
Hs Code.:

Synonyms:2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

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Chemical Property of 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

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Technology Process of 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

There total 9 articles about 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1168133-85-4
cyclopropylmethyl 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoate

: 1168114-17-7
2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

Guidance literature:: cyclopropylmethyl 2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoate; With ethanol; water; potassium hydroxide; for 2h; Reflux;

With hydrogenchloride; water; pH=5;

Reference yield: 90.0%

: 1073355-14-2
5?(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[c][1,2,5]oxadiazole

: 1168133-66-1
2-(5-cyclopropylmethoxy-2-fluoro-4-iodophenyl)-4-methylpentanoic acid cyclopropylmethyl ester

: 1168114-17-7
2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 18h; Inert atmosphere;

Reference yield:

: 2105-61-5
1,2,4-trifluoro-5-nitrobenzene

: 1168114-17-7
2-(4-(benzo[c][1,2,5]oxadiazol-5-yl)-5-(cyclopropylmethoxy)-2-fluorophenyl)-4-methylpentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.83 h / 0 - 20 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: acetic acid / water; ethanol / 96 h / Reflux

3.1: sulfuric acid / 3 h / Reflux

4.1: n-butyllithium / hexane / 1 h / -15 - 25 °C / Inert atmosphere

4.2: 16 h / 25 °C

5.1: hydrogen; palladium 10% on activated carbon / ethanol / 24 h / 25 °C / 2585.81 Torr

6.1: sodium nitrite; sulfuric acid / water; ethanol / 0.33 h / 0 °C

6.2: 2.5 h / 0 - 60 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride / N,N-dimethyl-formamide / 18 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium hydride; acetic acid; cesium fluoride; sodium nitrite; In ethanol; hexane; water; N,N-dimethyl-formamide; mineral oil;