N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane

Base Information

• Chemical Name: N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane
• CAS No.: 97879-29-3
• Molecular Formula: C₂₄H₃₇BrN₂O₃
• Molecular Weight: 481.473
• Mol file: 97879-29-3.mol

Synonyms:N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane

Chemical Property of N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane

There total 2 articles about N⁸-<3-(o-allylphenoxy)-2-hydroxypropyl>-N¹-(bromoacetyl)-(E)-1,8-diamino-p-menthane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-1,8-dinitro-p-menthane (58940-69-5) → N8-<3-(o-allylphenoxy)-2-hydroxypropyl>-N1-(bromoacetyl)-(E)-1,8-diamino-p-menthane (97879-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80.4 percent / H₂ / 10percent Pd/C / ethanol / 48 h / 760 Torr / Ambient temperature

2: 1.) 70 deg C, 16 h, 2.) ethyl acetate, 0 deg C, 20 min

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00149a028

Reference yield:

1-(2-allylphenoxy)-2,3-epoxypropane (4638-04-4) + 2-Bromoacetyl bromide (598-21-0) + (E)-1,8-diamino-p-menthane (54166-25-5) → N8-<3-(o-allylphenoxy)-2-hydroxypropyl>-N1-(bromoacetyl)-(E)-1,8-diamino-p-menthane (97879-29-3) + N1-<3-(o-allylphenoxy)-2-hydroxypropyl>-N8-(bromoacetyl)-(E)-1,8-diamino-p-menthane (97879-28-2,76298-89-0,81344-06-1,82870-40-4) + N1,N8-bis<3-(o-allylphenoxy)-2-hydroxypropyl>-(E)-1,8-diamino-p-menthane (97879-23-7)

Guidance literature:

Yield given. Multistep reaction. Yields of byproduct given; 1.) 70 deg C, 16 h, 2.) ethyl acetate, 0 deg C, 20 min;

DOI:10.1021/jm00149a028

upstream raw materials:

1-(2-allylphenoxy)-2,3-epoxypropane

2-Bromoacetyl bromide

(E)-1,8-diamino-p-menthane

(E)-1,8-dinitro-p-menthane