(2R,3S)-(+)-3-(BENZYLOXYMETHYL)OXIRANE-2-METHANOL 4-NITROBENZOIC ACID ESTER

Base Information

• Chemical Name: (2R,3S)-(+)-3-(BENZYLOXYMETHYL)OXIRANE-2-METHANOL 4-NITROBENZOIC ACID ESTER
• CAS No.: 78469-86-0
• Molecular Formula: C18H17 N O6
• Molecular Weight: 343.336
• Hs Code.: 2916399090
• Mol file: 78469-86-0.mol

Synonyms:Oxiranemethanol,3-[(phenylmethoxy)methyl]-, 4-nitrobenzoate, (2R,3S)- (9CI); Oxiranemethanol,3-[(phenylmethoxy)methyl]-, 4-nitrobenzoate, (2R-cis)-

Chemical Property of (2R,3S)-(+)-3-(BENZYLOXYMETHYL)OXIRANE-2-METHANOL 4-NITROBENZOIC ACID ESTER

Chemical Property:

• Vapor Pressure: 1.69E-10mmHg at 25°C
• Melting Point: 78-80 °C
• Refractive Index: 1.588
• Boiling Point: 509.5°C at 760 mmHg
• Flash Point: 212.4°C
• PSA: 93.88000
• Density: 1.299g/cm³
• LogP: 3.25900

Purity/Quality:

99% ^*data from raw suppliers

((2R,3S)-3-((Benzyloxy)methyl)oxiran-2-yl)methyl 4-nitrobenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,3S)-(+)-3-(BENZYLOXYMETHYL)OXIRANE-2-METHANOL 4-NITROBENZOIC ACID ESTER

There total 1 articles about (2R,3S)-(+)-3-(BENZYLOXYMETHYL)OXIRANE-2-METHANOL 4-NITROBENZOIC ACID ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol (78513-07-2,78513-12-9,78513-15-2,84621-89-6,87172-27-8,95672-91-6,98048-62-5,98048-63-6,78469-85-9) + 4-nitro-benzoic acid (62-23-7) → 4-nitro-benzoic acid (2R,3S)-3-benzyloxymethyl-oxiranylmethyl ester (78469-86-0)

Guidance literature:

With pyridine; p-toluenesulfonyl chloride; for 0.75h; Ambient temperature;

DOI:10.1002/hlca.19810640311

Reference yield: 100.0%

4-nitro-benzoic acid (2R,3S)-3-benzyloxymethyl-oxiranylmethyl ester (78469-86-0) → ((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol (78513-07-2,78513-12-9,78513-15-2,84621-89-6,87172-27-8,95672-91-6,98048-62-5,98048-63-6,78469-85-9)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; ethanol; water; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2017.06.077

Reference yield: 94.0%

4-nitro-benzoic acid (2R,3S)-3-benzyloxymethyl-oxiranylmethyl ester (78469-86-0) → (-)-(2S,3R)-2,3-epoxy-4-(benzyloxy)-1-butanol (78513-07-2)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; methanol;

DOI:10.1016/S0957-4166(00)80273-6

upstream raw materials:

((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol

4-nitro-benzoic acid

Downstream raw materials:

(-)-(2S,3R)-2,3-epoxy-4-(benzyloxy)-1-butanol

((2R,3S)-3-((benzyloxy)methyl)oxiran-2-yl)methanol

(2R,3R)-3-[(benzyloxy)methyl]oxirane-2-carbaldehyde

3-((2S,3R)-3-Benzyloxymethyl-oxiranyl)-propionic acid methyl ester