(dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin

Base Information

• Chemical Name: (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin
• CAS No.: 1363189-47-2
• Molecular Formula: C₁₅H₁₀ClFO₂
• Molecular Weight: 276.695
• Mol file: 1363189-47-2.mol

Synonyms:(dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin

Chemical Property of (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin

There total 3 articles about (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H12ClFO3 (1363189-26-7) → (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin (1363189-47-2)

Guidance literature:

With acetic anhydride; for 1h; Inert atmosphere; Reflux;

DOI:10.1016/j.jfluchem.2011.11.011

Reference yield:

2-{2'-(3''-chloro-4''-fluorophenyl)-2'-oxoethyl}benzoic acid (1363189-06-3) → (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin (1363189-47-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; sodium hydroxide / water / 20 °C / Inert atmosphere

2: acetic anhydride / 1 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; acetic anhydride; sodium hydroxide; In water;

DOI:10.1016/j.jfluchem.2011.11.011

Reference yield:

3-(3'-chloro-4'-fluorophenyl)isocoumarin (1363188-90-2) → (dl)-3-(3'-chloro-4'-fluorophenyl)-3,4-dihydroisocoumarin (1363189-47-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / ethanol / 5 h / Reflux; Inert atmosphere

2: sodium tetrahydroborate; sodium hydroxide / water / 20 °C / Inert atmosphere

3: acetic anhydride / 1 h / Inert atmosphere; Reflux

With sodium tetrahydroborate; acetic anhydride; potassium hydroxide; sodium hydroxide; In ethanol; water;

DOI:10.1016/j.jfluchem.2011.11.011

upstream raw materials:

3-(3'-chloro-4'-fluorophenyl)isocoumarin

2-{2'-(3''-chloro-4''-fluorophenyl)-2'-oxoethyl}benzoic acid

C₁₅H₁₂ClFO₃