(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

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Chemical Name:(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester
CAS No.:611182-59-3
Molecular Formula:C₃₁H₃₉NO₄
Molecular Weight:489.655
Hs Code.:

Synonyms:(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

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Chemical Property of (S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

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Technology Process of (S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

There total 4 articles about (S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 611182-58-2
9-bromomrthyl-3,3-dimethyl-1,5-dioxa-spiro[5,5]undec-8-ene

: 611182-59-3
(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

: (R)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

Guidance literature:: With cesium hydroxide; (4R,5R)-2-tert-butyl-N,N,N',N'-tetrakis[(4-methoxyphenyl)methyl]-N,N',2-trimethyl-1,3-dioxolane-4,5-dimethanammonium diiodide; In dichloromethane; toluene; at -70 ℃; for 72h; Title compound not separated from byproducts;
DOI:10.1021/ja037290e

Reference yield:

: 2,4-dihydroanisylalcohol

: 611182-59-3
(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / BF₃Et₂O / tetrahydrofuran / 20 h / cooling

2: triethylamine / CH₂Cl₂ / 0.5 h / -78 °C

3: 2.39 g / NaBr / acetone / 20 °C

4: (R,R)-[(4-MeOBn)2N⁽¹⁺⁾(Me)CH₂]2-dioxolane-2-Me-2-tBu*2I^(1-); CsOH*H₂O / toluene; CH₂Cl₂ / 72 h / -70 °C

With cesium hydroxide; boron trifluoride diethyl etherate; triethylamine; sodium bromide; (4R,5R)-2-tert-butyl-N,N,N',N'-tetrakis[(4-methoxyphenyl)methyl]-N,N',2-trimethyl-1,3-dioxolane-4,5-dimethanammonium diiodide; In tetrahydrofuran; dichloromethane; acetone; toluene;
DOI:10.1021/ja037290e

Reference yield:

: 611182-94-6
(3,3-dimethyl-1,5-dioxa-spiro[5,5]undec-8-en-9-yl)methanol

: 611182-59-3
(S)-2-(benzhydrylideneamino)-3-(3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-8-en-9-yl)propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / CH₂Cl₂ / 0.5 h / -78 °C

2: 2.39 g / NaBr / acetone / 20 °C

3: (R,R)-[(4-MeOBn)2N⁽¹⁺⁾(Me)CH₂]2-dioxolane-2-Me-2-tBu*2I^(1-); CsOH*H₂O / toluene; CH₂Cl₂ / 72 h / -70 °C

With cesium hydroxide; triethylamine; sodium bromide; (4R,5R)-2-tert-butyl-N,N,N',N'-tetrakis[(4-methoxyphenyl)methyl]-N,N',2-trimethyl-1,3-dioxolane-4,5-dimethanammonium diiodide; In dichloromethane; acetone; toluene;
DOI:10.1021/ja037290e