ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate

Base Information

• Chemical Name: ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate
• CAS No.: 1174757-01-7
• Molecular Formula: C₁₈H₂₇O₅P
• Molecular Weight: 354.383
• Mol file: 1174757-01-7.mol

Synonyms:ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate

Chemical Property of ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate

There total 3 articles about ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

diisopropyl phosphorochloridite (41662-51-5) + ethyl 2-(hydroxy(phenyl)methyl)propenoate (37442-45-8) → ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate (1174757-01-7)

Guidance literature:

diisopropyl phosphorochloridite; ethyl 2-(hydroxy(phenyl)methyl)propenoate; With triethylamine; In diethyl ether; at -10 ℃; Inert atmosphere;

at 70 - 100 ℃; Inert atmosphere;

DOI:10.1021/ol9012469

Reference yield:

ethyl 2-(hydroxy(phenyl)methyl)propenoate (37442-45-8) → ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate (1174757-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 0.33 h / -10 °C / Inert atmosphere

2: 70 - 100 °C / Inert atmosphere

With triethylamine; In diethyl ether;

DOI:10.1016/j.tetasy.2011.12.002

Reference yield:

ethyl acrylate (140-88-5,9003-32-1) → ethyl (Z)-2-[(diisopropoxyphosphoryl)methyl]-3-phenyl-2-propenoate (1174757-01-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / PEG-400 / 20 °C / Inert atmosphere

2: triethylamine / diethyl ether / 0.33 h / -10 °C / Inert atmosphere

3: 70 - 100 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In PEG-400; diethyl ether; 1: Baylis-Hillman reaction;

DOI:10.1016/j.tetasy.2011.12.002

upstream raw materials:

diisopropyl phosphorochloridite

ethyl 2-(hydroxy(phenyl)methyl)propenoate

ethyl acrylate

Downstream raw materials:

C₁₈H₂₉O₅P