Technology Process of 2-fluoro-4-(1-methyl-1H-tetrazol-5-yl)phenol
There total 4 articles about 2-fluoro-4-(1-methyl-1H-tetrazol-5-yl)phenol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
formic acid; palladium;
In
tetrahydrofuran; ethanol;
at 20 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 0.17 h
1.2: 70 h / 20 °C
2.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 110 °C
2.2: 20 °C / pH 3
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C
3.2: 15 h / 20 °C / Inert atmosphere
4.1: formic acid / palladium / ethanol; tetrahydrofuran / 4 h / 20 °C
With
formic acid; sodium azide; sodium hydride; potassium carbonate; ammonium chloride;
palladium;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 18 h / 110 °C
1.2: 20 °C / pH 3
2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 20 °C
2.2: 15 h / 20 °C / Inert atmosphere
3.1: formic acid / palladium / ethanol; tetrahydrofuran / 4 h / 20 °C
With
formic acid; sodium azide; sodium hydride; ammonium chloride;
palladium;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil;
