(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

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Chemical Name:(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine
CAS No.:153785-24-1
Molecular Formula:C₂₇H₂₃N₅O₁₀S
Molecular Weight:609.573
Hs Code.:

Synonyms:(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

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Chemical Property of (2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

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Technology Process of (2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

There total 5 articles about (2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R) 1-(1'-p-nitrobenzyl-oxycarbonyl-2'-methyl-prop-2'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)aminosulfinyl]-3-phthalimido-4-oxo-azetidine

: (2R,3R) 1-(1'-p-Nitrobenzyloxycarbonyl-2'-methyl-prop-2'-enyl)-2-[(5'methyl-isoxazol-3'-yl)aminosulfonyl]-3-phthalimido-4-oxo-azetidine

: 153785-08-1
(2R,3R) 1-(1'-p-nitrobenzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)aminosulfinyl]-3-phthalimido-4-oxo-azetidine

: 153785-24-1
(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

Guidance literature:: With triethylamine; In dichloromethane;

Reference yield:

: 153785-08-1
(2R,3R) 1-(1'-p-nitrobenzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)aminosulfinyl]-3-phthalimido-4-oxo-azetidine

: 153785-24-1
(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

Guidance literature:: With formic acid; dihydrogen peroxide; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4020(01)80182-4

Reference yield:

: 40028-92-0
6-phthalimidopenicillanate sulphoxide p-nitrobenzyl ester

: 153785-24-1
(2R,3R) 1-(1'-p-nitro-benzyloxycarbonyl-2'-methyl-prop-1'-enyl)-2-[(5'-methyl-isoxazol-3'-yl)amino-sulfonyl]-3-phthalimido-4-oxo-azetidine

Guidance literature:: Multi-step reaction with 4 steps

1: N-chlorosuccinimide / toluene / 1.5 h / Heating

2: toluene / 4 h / 10 °C

3: triethylamine / CH₂Cl₂ / 2 h / Ambient temperature

4: formic acid, 30percent aqueous H₂O₂ / CH₂Cl₂ / Ambient temperature

With N-chloro-succinimide; formic acid; dihydrogen peroxide; triethylamine; In dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)80182-4