ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate

Base Information

• Chemical Name: ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate
• CAS No.: 220951-69-9
• Molecular Formula: C₁₈H₂₇NO₇S
• Molecular Weight: 401.481
• Mol file: 220951-69-9.mol

Synonyms:ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate

Chemical Property of ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate

There total 1 articles about ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2-dimethyl-propanol-1 (75-84-3) + (R)-2-benzyloxycarbonylamino-3-chlorosulfopropanoic acid ethyl ester (23926-59-2) → ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate (220951-69-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.666667h;

DOI:10.1021/jo9812680

Reference yield: 97.0%

ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate (220951-69-9) → 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoic acid (220951-71-3)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 14h;

DOI:10.1021/jo9812680

Reference yield:

ethyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate (220951-69-9) → tert-butyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate (220951-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / aq. HCl / dioxane / 14 h / 50 °C

2: 33 percent / H₂SO₄ / diethyl ether / 168 h / -78 - 20 °C

With hydrogenchloride; sulfuric acid; In 1,4-dioxane; diethyl ether; 1: Hydrolysis / 2: Esterification;

DOI:10.1021/jo9812680

upstream raw materials:

2,2-dimethyl-propanol-1

(R)-2-benzyloxycarbonylamino-3-chlorosulfopropanoic acid ethyl ester

Downstream raw materials:

2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoic acid

tert-butyl 2(S)-2-[(benzyloxycarbonyl)amino]-3-(neopentyloxysulfonyl)propanoate