(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

Base Information

Chemical Name:(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde
CAS No.:1373497-76-7
Molecular Formula:C₁₉H₁₈O₅
Molecular Weight:326.349
Hs Code.:

Synonyms:(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

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Chemical Property of (E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

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Technology Process of (E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

There total 2 articles about (E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 3328-73-2
4-hydroxy-5-methylisophthalaldehyde

: 1131-62-0
1-(3,4-dimethoxyphenyl)ethanone

: 1373497-76-7
(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

Guidance literature:: With boron trifluoride diethyl etherate; In 1,4-dioxane; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1248/cpb.c15-00939

Reference yield:

: 95-48-7,77504-84-8
ortho-cresol

: 1373497-76-7
(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / 120 °C

2: boron trifluoride diethyl etherate / 1,4-dioxane / 24 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; trifluoroacetic acid; In 1,4-dioxane; 1: |Duff Aldehyde Synthesis / 2: |Claisen-Schmidt Condensation;
DOI:10.1248/cpb.c15-00939

Reference yield: 92.0%

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1373497-76-7
(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde

: 1373497-72-3
(E)-3-(3,4-dimethoxyphenyl)-6-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-8-methyl-2H-chromen-2-one

Guidance literature:: (3,4-Dimethoxyphenyl)acetic acid; With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(E)-5-(3-(3,4-dimethoxyphenyl)-3-oxoprop-1-enyl)-2-hydroxy-3-methylbenzaldehyde; In N,N-dimethyl-formamide; at 110 ℃; for 1.41667h;
DOI:10.1055/s-0031-1290344