6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Base Information

Chemical Name:6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid
CAS No.:1336965-72-0
Molecular Formula:C₂₇H₂₇F₄N₃O₃
Molecular Weight:517.523
Hs Code.:

Synonyms:6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Suppliers and Price of 6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

There total 4 articles about 6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1336965-70-8
3-(bromomethyl)-6-fluoro-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

: 53617-35-9
4-(piperidin-4-yl)morpholine

: 1336965-72-0
6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: With sodium carbonate; In acetonitrile; at 55 ℃;

Reference yield:

: 1533-03-5
3-(trifluoromethyl)propiophenone

: 1336965-72-0
6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 6

2.1: dibenzoyl peroxide; N-Bromosuccinimide; acetic acid / tetrachloromethane / 20 °C / Reflux

3.1: sodium carbonate / acetonitrile / 55 °C

With N-Bromosuccinimide; sodium carbonate; acetic acid; potassium hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; acetonitrile;

Reference yield:

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 1336965-72-0
6-fluoro-3-{[4-(4-morpholinyl)-1-piperidinyl]methyl}-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 0.25 h

1.2: 1 h / Reflux

1.3: pH 6

2.1: dibenzoyl peroxide; N-Bromosuccinimide; acetic acid / tetrachloromethane / 20 °C / Reflux

3.1: sodium carbonate / acetonitrile / 55 °C

With N-Bromosuccinimide; sodium carbonate; acetic acid; potassium hydroxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; water; acetonitrile;