C₃₂H₄₃NO₉

Base Information

• Chemical Name: C₃₂H₄₃NO₉
• CAS No.: 1404078-90-5
• Molecular Formula: C₃₂H₄₃NO₉
• Molecular Weight: 585.695
• Mol file: 1404078-90-5.mol

Synonyms:C₃₂H₄₃NO₉

Chemical Property of C₃₂H₄₃NO₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₃NO₉

There total 17 articles about C₃₂H₄₃NO₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C46H65NO10Si (1404078-86-9) → C40H51NO10 (1404078-88-1) + C32H43NO9 (1404078-90-5)

Guidance literature:

With pyridine; hydrogenchloride; hydrogen fluoride; In tetrahydrofuran; water; at 20 ℃; for 14h;

DOI:10.1039/c2ob26256h

Reference yield:

(2S,3R)-3-(4-methoxybenzyloxy)-2-methylpentanal (627511-81-3) → C40H51NO10 (1404078-88-1) + C32H43NO9 (1404078-90-5)

Guidance literature:

Multi-step reaction with 12 steps

1.1: titanium tetrachloride / dichloromethane / 0.33 h / -50 °C

1.2: 2 h / -40 °C

1.3: 2 h / -78 °C

2.1: 2,6-dimethylpyridine / dichloromethane / 3 h / -78 - 20 °C

3.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

4.2: 72 h / 20 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C

6.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C

8.1: potassium carbonate / methanol / 0 - 20 °C

9.1: Schwartz's reagent / tetrahydrofuran / 1 h / 0 °C

9.2: 0.67 h / -78 °C / Darkness

10.1: tert.-butyl lithium / pentane; diethyl ether / 1 h / -78 °C / Inert atmosphere

10.2: 0.25 h / -78 °C

10.3: 3 h / -78 °C

11.1: dmap; pyridine / dichloromethane / 16 h / 20 °C

12.1: pyridine; hydrogenchloride; hydrogen fluoride / tetrahydrofuran; water / 14 h / 20 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; dmap; Schwartz's reagent; diethylamino-sulfur trifluoride; hexamethylenetetramine; hydrogen fluoride; dihydrogen peroxide; tert.-butyl lithium; titanium tetrachloride; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; pentane;

DOI:10.1039/c2ob26256h

Reference yield:

(3S,4R,5R)-3-(tert-butyldimethylsilyloxy)-1-[(R)-4-isopropyl-2-thioxothiazolidin-3-yl]-5-(4-methoxybenzyloxy)-4-methylheptan-1-one → C40H51NO10 (1404078-88-1) + C32H43NO9 (1404078-90-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 3 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol / dichloromethane / 2 h / 20 °C

2.2: 72 h / 20 °C

3.1: diethylamino-sulfur trifluoride / dichloromethane / 2 h / -78 °C

4.1: copper(ll) bromide; hexamethylenetetramine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h / 20 °C

5.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.75 h / -78 °C

6.1: potassium carbonate / methanol / 0 - 20 °C

7.1: Schwartz's reagent / tetrahydrofuran / 1 h / 0 °C

7.2: 0.67 h / -78 °C / Darkness

8.1: tert.-butyl lithium / pentane; diethyl ether / 1 h / -78 °C / Inert atmosphere

8.2: 0.25 h / -78 °C

8.3: 3 h / -78 °C

9.1: dmap; pyridine / dichloromethane / 16 h / 20 °C

10.1: pyridine; hydrogenchloride; hydrogen fluoride / tetrahydrofuran; water / 14 h / 20 °C

With pyridine; hydrogenchloride; dmap; Schwartz's reagent; diethylamino-sulfur trifluoride; hexamethylenetetramine; hydrogen fluoride; dihydrogen peroxide; tert.-butyl lithium; diisobutylaluminium hydride; potassium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; copper(ll) bromide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; pentane;

DOI:10.1039/c2ob26256h

upstream raw materials:

(2S,3R)-3-(4-methoxybenzyloxy)-2-methylpentanal

(3S,4R,5R)-3-(tert-butyldimethylsilyloxy)-5-(4-methoxybenzyloxy)-4-methylheptanoic acid

methyl [2-(2S,3R,4R)-2-(tert-butyldimethylsilyloxy)-[4-(4-methoxybenzyloxy)-3-methylhexyl]]oxazol-4-carboxylate

C₃₉H₄₇NO₆S