(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

Base Information

Chemical Name:(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol
CAS No.:652156-83-7
Molecular Formula:C₂₁H₂₈N₂O₂
Molecular Weight:340.466
Hs Code.:

Synonyms:(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

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Technology Process of (S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

There total 10 articles about (S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 324753-74-4
((4R,5S)-5-Isopropyl-2,2-dimethyl-4-vinyl-oxazolidin-3-yl)-diphenyl-amine

: 652156-83-7
(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

Guidance literature:: ((4R,5S)-5-Isopropyl-2,2-dimethyl-4-vinyl-oxazolidin-3-yl)-diphenyl-amine; With osmium(VIII) oxide; In 1,4-dioxane; water; at 20 ℃; for 1h;

With sodium periodate; In 1,4-dioxane; water; for 24h;

With sodium tetrahydroborate; In methanol; at 0 ℃; for 12h; Further stages.;
DOI:10.1021/ol0067991

Reference yield:

: (4S,5S)-3-Diphenylamino-5-isopropyl-2,2-dimethyl-oxazolidine-4-carbaldehyde

: 652156-83-7
(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 12h;
DOI:10.1021/jo035405r

Reference yield:

: 136779-39-0
(S)-methyl 2-(tert-butyldimethylsilyloxy)-3-methylbutanal

: 652156-83-7
(S)-1-((R)-3-Diphenylamino-2,2-dimethyl-oxazolidin-4-yl)-2-methyl-propan-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1: 0.756 g / pyridine / toluene / 20 °C

2: 88 percent / Bu₄NF / tetrahydrofuran / 20 °C

3: 92 percent / Et₃N / CH₂Cl₂ / 5 h / 0 - 20 °C

4: AIBN / cyclohexane / Heating

5: KF / methanol / 20 h / 20 °C

6: PPTS / CHCl₃ / 24 h / 20 °C

7: OsO₄ / dioxane; H₂O / 1 h / 20 °C

8: NaIO₄ / dioxane; H₂O / 24 h

9: NaBH₄ / methanol / 12 h / 0 °C

With pyridine; potassium fluoride; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; cyclohexane; water; toluene;
DOI:10.1021/jo035405r