ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate
CAS No.:897439-71-3
Molecular Formula:C₁₉H₁₅F₄NO₂
Molecular Weight:365.327
Hs Code.:

Synonyms:ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

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Chemical Property of ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

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Technology Process of ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

There total 1 articles about ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 456-42-8
m-fluorobenzyl chloride

: 897439-71-3
ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

Guidance literature:: ethyl 5-(trifluoromethyl)-1H-indole-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 2h;

m-fluorobenzyl chloride; In N,N-dimethyl-formamide; for 28h;

Reference yield:

: 897439-71-3
ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

: N-(1-methyl-1H-indazol-5-yl)-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide

Guidance literature:: 1-methyl-1H-indazol-5-amine; With trimethylaluminum; In toluene; at 0 - 50 ℃; for 0.5h;

ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate; In toluene; for 3h; Heating / reflux;

Reference yield:

: 897439-71-3
ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate

: N-(1,2,3,4-tetrahydroquinolin-7-yl)-5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxamide

Guidance literature:: 7-amino-1,2,3,4-tetrahydroquinoline; With trimethylaluminum; In toluene; at 0 - 50 ℃; for 2h;

ethyl 5-trifluoromethyl-1-[(3-fluorophenyl)methyl]-1H-indole-2-carboxylate; In toluene; for 3h; Heating / reflux;