4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile

Base Information

• Chemical Name: 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile
• CAS No.: 708208-66-6
• Molecular Formula: C₂₁H₂₄N₄O₂
• Molecular Weight: 364.447
• Mol file: 708208-66-6.mol

Synonyms:4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile

Chemical Property of 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile

There total 7 articles about 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

toluene-4-sulfonic acid 5-(4-cyano-phenoxy)-3-methyl-pentyl ester (853644-39-0) + 1-(pyridin-4-yl)-2-imidazolidinone (52210-90-9) → 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile (708208-66-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm050033v

Reference yield:

dimethyl glutaconate (5164-76-1) → 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile (708208-66-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: CuI / tetrahydrofuran / 20 °C

1.2: TMSCl / tetrahydrofuran / -78 - 20 °C

2.1: lithium aluminum hydride / tetrahydrofuran / 24 h / Heating

3.1: pyridine / 2 h / 20 °C

4.1: 0.83 g / K₂CO₃ / acetonitrile / 24 h / 60 °C

5.1: 91 percent / NaH / dimethylformamide / 20 °C

With pyridine; copper(l) iodide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.2: Michael addition;

DOI:10.1021/jm050033v

Reference yield:

3-methylpentane-1,5-diyl bis(4-methylbenzenesulfonate) (148054-23-3) → 4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzonitrile (708208-66-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.83 g / K₂CO₃ / acetonitrile / 24 h / 60 °C

2: 91 percent / NaH / dimethylformamide / 20 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm050033v

upstream raw materials:

toluene-4-sulfonic acid 5-(4-cyano-phenoxy)-3-methyl-pentyl ester

1-(pyridin-4-yl)-2-imidazolidinone

3-methylpentane-1,5-diyl bis(4-methylbenzenesulfonate)

4-aminopyridine

Downstream raw materials:

N-hydroxy-4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzamidine

N-hydroxy-4-[3-methyl-5-(2-oxo-3-pyridin-4-yl-imidazolidin-1-yl)-pentyloxy]-benzamidine