6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

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Chemical Name:6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile
CAS No.:106412-61-7
Molecular Formula:C₁₅H₁₃ClN₄O
Molecular Weight:300.747
Hs Code.:

Synonyms:6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

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Chemical Property of 6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

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Technology Process of 6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

There total 5 articles about 6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 106412-55-9
2-Dicyanomethylene-1-methyl-pyrrolidine-3-carboxylic acid (4-chloro-phenyl)-amide

: 106412-61-7
6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

Guidance literature:: With sodium ethanolate; In ethanol; Ambient temperature;

Reference yield:

: 104-12-1
p-chlorphenylisocyanate

: 106412-61-7
6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) THF, from -78 deg C to RT

2: acetone

3: 86 percent / triethylbenzylammonium chloride, KF / CH₂Cl₂ / 15 h / Ambient temperature

4: 76 percent / NaOC₂H₅ / ethanol / Ambient temperature

With potassium fluoride; n-butyllithium; N-benzyl-N,N,N-triethylammonium chloride; sodium ethanolate; In ethanol; dichloromethane; acetone;

Reference yield:

: 106412-49-1
1-Methyl-2-thioxo-pyrrolidine-3-carboxylic acid (4-chloro-phenyl)-amide

: 106412-61-7
6-Amino-5-(4-chloro-phenyl)-1-methyl-4-oxo-2,3,4,5-tetrahydro-1H-pyrrolo[3,2-c]pyridine-7-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: acetone

2: 86 percent / triethylbenzylammonium chloride, KF / CH₂Cl₂ / 15 h / Ambient temperature

3: 76 percent / NaOC₂H₅ / ethanol / Ambient temperature

With potassium fluoride; N-benzyl-N,N,N-triethylammonium chloride; sodium ethanolate; In ethanol; dichloromethane; acetone;