(10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Base Information

Chemical Name:(10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one
CAS No.:88981-67-3
Molecular Formula:C₃₁H₂₈N₂O₄S₂
Molecular Weight:556.706
Hs Code.:

Synonyms:(10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

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Chemical Property of (10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

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Technology Process of (10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

There total 19 articles about (10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 88981-66-2
(+)-1-<(p-tolyl-(R)-sulfinyl)acetyl>-cis-2,3,4,4a(R),5(R),6,7,11c(S)-octahydro-5α(R)-chloro-7-<(p-methoxyphenyl)sulfonyl>-1H-pyrido<3,2-c>carbazole

: 88981-67-3
(10bS,11S,12bS)-6-(4-Methoxy-benzenesulfonyl)-11-p-tolylsulfanyl-2,3,6,12b-tetrahydro-1H-6,12a-diaza-indeno[7,1-cd]fluoren-12-one

Guidance literature:: With trifluoroacetic anhydride; In dichloromethane; chlorobenzene; at 130 ℃;
DOI:10.1039/c39850000184

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 88981-67-3,88981-68-4,89016-47-7,89016-48-8
(-)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11β-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, 0 deg C, 0.25 h; 2.) 1 h

2: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 12 h / 25 °C

3: 1.) (CF₃CO)2O; 2.) chlorobenzene / 1.) CH₂Cl₂, 0 ->25 deg C, 0.5 h; 2.) 120 deg C, 6 h

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; chlorobenzene; trifluoroacetic anhydride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00319a034

Reference yield:

: 1519-39-7
(R)-methyl p-tolyl sulfoxide

: 88981-67-3,88981-68-4,89016-47-7,89016-48-8
(+)-2,3,4,5-tetradehydro-1-<(p-methoxyphenyl)sulfonyl>-11α-(p-tolylthio)-20,21-dinoraspidospermidin-10-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA / 1.) THF, 0 deg C, 0.25 h; 2.) 1 h

2: 47 percent / 1-cyclohexyl-3-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate / CH₂Cl₂ / 12 h / 25 °C

3: 1.) (CF₃CO)2O; 2.) chlorobenzene / 1.) CH₂Cl₂, 0 ->25 deg C, 0.5 h; 2.) 120 deg C, 6 h

With N-cyclohexyl-N'-β-(4-methylmorpholinium)ethylcarbodiimide p-toluenesulfonate; chlorobenzene; trifluoroacetic anhydride; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/ja00319a034